| Sammie | Sampeace Brown | Samson Jones |
| Sandra | Sandy | Sanjay & Jimmy Cliff |
| Santalina | Santana | Sarah Connor Feat. Tq |
| Sarah Connor featuring TQ | Sarah Dash | Sarah Lesol |
| Sarah Riani | Sarah-Ann | Sarrina K. |
| Sash Mckay | Sasha | Sasha Strunin |
| Saskia Garel | Satomi' | Savoir Flair |
| Scola (of Dru Hill) | Scottie | Scotty Rebel Feat. French Montana |
| Se7en | Seabron | Seal |
| Sean Baker | Sean Garrett | Sean Gemini |
| Sean Kingston | Sean Kingston & Mavado | Sean Levert |
| Sean Miranda | Sean Oliver | Sean Paul |
| Sean Paul & Mya | Sean Rasul | Sean Simmonds |
| Sean1 | Second Image | Secret |
| Seejai | Seek | Sef Gaines |
| Seize Neuf | Seizeneuf | Selah |
| Selena 7ty Six | Selena Serrano | Selwyn |
| Serani | Sergio Mendes | Serom |
| Seven Feat. Talib Kweli | Severin | Sg Wannabe |
| Sha | Shades Of Lace | Shadiya |
| Shae Fiol | Shaggy | Shaggy & Di Genius |
| Shaggy, Damian Marley, Tarrus Riley, Romain Virgo, Wayne Marshall, Tifa, Tessane Chin, Chevelle Franklyn, Beres Hammond & Assassin | Shaggy, Sean Paul, Sean Kingston, Etana, Tessane, Alison Hinds & Destra | Shah |
| Shai | Shakatak | Shakaya |
| Shakira featuring Wyclef Jean | Shalamar | Shaleah |
| Shana | Shane Anderson | Shane Forrester |
| Shang | Shanice | Shanice Wilson |
| Shannon | Shannon Alvares | Shannone Holt |
| Shantel | Shara Nelson | Shareefa |
| Shareefa (featuring Ludacris) | Shareefa featuring Ludacris | Shareiff Robinson |
| Shari Tanizawa | Sharifa | Sharissa |
| Sharissa Feat. R. Kelly | Sharissa Ft The Game | Sharlene |
| Sharon Jones And The Dap-Kings | Sharon Redd | Sharp |
| Shaun Escoffery | Shaun H Mykals | Shaune C |
| Shawn Berry | Shawn Emanuel | Shawn Everette |
| Shawn Heckstall | Shawn Powell | Shawty Redd |
| Shayna Steele | Shaznay Lewis | Shea |
| Shean Williams | Shei Atkins | Sheila E |
| Sheila E. | Sheila G | Sheila Gathright |
| Shelly Feat Cassidy | Shelly Nicole'S Blakbüshe | Sheryfa Luna |
| Shion | Shire | Shirley Ellis |
| Shirley Murdock | Shiron Denise | Sho |
| Shola Ama | Shona | Shonie Ft Fabolous |
| Shontelle | Shontelle Ft Akon | Shortee Redd Ft Mya |
| Shorty Corleone | Shorty-E | Shoshyn |
| Shot Callaz | Shu | Shuggie Otis |
| Shy'M | Shym | Shyneze |
| Shyneze | Sia | Siani |
| Siba | Sichelle | Side F-X |
| Siedah Garrett | Siji | Silena Murrell |
| Silk | Silver Cat | Silver Cat & Hero |
| Silver Ft Kardinal Offishall | Simeo | Simeyon |
| Simon De | Simon Webbe | Simone Elizabeth |
| Simple Pleasure | Simz | Sincere |
| Singuila | Sinister Shan | Sir J |
| Sirens | Sisaundra Lewis | Sisqo |
| Sista Scenario & Soukeyna | Sistars | Sister Sledge |
| Sizzla | Sj | Sk Radicals |
| Skeet Mitchell | Ski Johnson | Skillz |
| Skin Deep | Skipper Dean & Dr Soul | Skool Boyz |
| Skoop on Somebody | Skooter Max | Skrilla |
| Skwares | Skye | Skyrelli And Brobick |
| Slabofmisuse | Slakah The Beatchild | Slave |
| Sleepy Brown | Slim | Slique |
| Sly And Robbie And Unitzz | Sly and The Family Stone | Sly Fidelity |
| Sly Fidelity And Club Foot | Sly Fidelity And Clubfoot | Slyde |
| Small Change | Smi | Smilez And Southstar Ft Kc |
| Smithmonger | Smitty Feat. Lil Wayne & Twsista | Smoke |
| Smoke E. Digglera | Smokey Robinson | Smokey Robinson and The Miracles |
| Smooove Talk | Smooth | Smooth Approach |
| Smoothtone | Smuji Feat. Fya | Smujji |
| Smuv | Snoop Dogg Ft Lil Kim | So Freak So Chic |
| So Solid Crew | Soccx | Sofa |
| Sofia Hayat | Sol | Solange |
| Solomon | Solomon Burke | Solomon Jaye |
| Solomon Wyatt | Solution | Soma |
| Somi | Son D-Lyte | Songbyrd Jackson |
| Sonia Many | Soraya | SOS Band |
| Soul Bros | Soul City | Soul Divine |
| Soul Essence | Soul Folk Featuring Will Hammond Jr. | Soul For Real |
| Soul Harmonics | Soul Id & Dmust Akira | Soul II Soul |
| Soul IV Real | Soul Kitchen-Band | Soul Of A Man |
| Soul:Id | Souleye Feat. Sodad | Soulfinger Experience |
| Soulfruit | Soulganic | Soulhead |
| Soulid | Soulive | Soulja Boy |
| Soulstar | Soundbwoy | Soundbwoy Ent |
| Soundbwoy Ent aka Sbe | Soundbwoy Entertainment | Sounds of Pleasure and DJ Finesse present |
| Spacifix | Spanky Wilson | Sparkle |
| Special | Special Generation | Specialist & Ishawna |
